Eosinophils is a type of white blood cells i.e. WBC. Eosinophilic pneumonia is a example of group of lung diseases in which eosinophils (a type of white blood cell) appear in increased numbers in the lungs and usually in the blood stream. These cells cause disruption of the normal air spaces i.e. Alveoli. The medications abuse gives Eosinophilic pneumonia for example; NSAID, Phenytoin, Nitrofurantoin, L-tryptophan and Daptomycin abuse, Inhalation of Heroin, cocaine etc. Chemicals such as Aluminum Silicates and Cigarette Smoking can cause EP. Parasites cause Eosinophilic pneumonia EP in three different ways. Parasites can either invade the lung; live in the lung as part of life cycle or to be spread to the lung by the blood stream. Eosinophilic pneumonia (EP) is diagnosed by a combination of characteristic symptoms or by physical examination or by blood tests and X-rays.
A reversed phase high performance liquid chromatography (RP-HPLC) consist of simple, isocratic, and accurate method was developed for quantitative estimation of Atorvastatin and Clopidogrel in marketed capsule formulation. The chromatographic separation was achieved on a C18 column using a mixture of phosphate buffer (pH= 3.0): Acetonitrile (40:60) as a mobile phase and UV detection at 242nm. Atorvastatin and Clopidogrel eluted at retention time 6.90 and 10.05 respectively. Current method was validated with respect to precision, accuracy, linearity, robustness according to ICH guidelines. Atorvastatin, Clopidogrel and their combination drug product was subjected to stress conditions (acid, base, oxidation, thermal, humidity and photolysis). Major degradation was found under thermal and humidity stress conditions while only a minor degradation was observed during photolysis.
The manuscript describes the concise, efficient and cost effective route of synthesis of (3R, 3aS, and 6aR)-hexahydrofuro [2, 3-b] furan-3-yl acetate, a key unit for an antiretroviral medication, Darunavir (DRV), used for the treatment and prevention of HIV/AIDS. The process involves the use of an immobilized enzyme to circumvent tedious work up problems like celitefiltration, giving away the final product with higher yield and purity. The investigational studies done in this article will surely aid in improving the existing processes in many aspects as discussed above.
Development of newly synthesized Antibacterial agents. In the present work substituted benzoic acid hydrazides were condensed with substituted aromatic and hetroaromatic aldehydes to yield to be target products (7, 9, 12). The synthesized compounds were tested for in vitro Antibacterial activities against Gram Positive, Gram negative bacteria and Standard drugs (Fluconazaole). The Evaluation of antibacterial activity study in a zone of inhibition was determined by cup plate method. (Bacteria) for 24 hrs and at 25°C (fungi) for 3 days and the results were recorded Growth of microorganism.
In order to have a superior graft of coronary artery bypass graft surgery, the study evaluates the early and intermediate results of radial artery grafts in coronary artery bypass graft surgery. 147 patients were faced with coronary artery bypass graft surgery from September 2008 to February 2016, their mean age was 63 ± 10.02 years, men accounted for 74.83%. With 160 radial artery graftings are connected to the bypasses of left coronary artery 87.07% and right coronary artery 12.93%. A total of 81 patients were enrolled in coronary artery by cardiac catheterization and a 64-slice CT scan, the rate of left Internal Thoracic Artery and right Internal Thoracic Artery were 98.77% and 93.75% respectively, the rate of the radial artery was 92.85% and the rate of saphenous vein grafts was 82.5%. There were no cases of premature death within 30 days after surgery. 142 patients were monitored, mean: 55 ± 4.8 months (18 months, 60 months), 9.86% patients had recurrent chest pain. The median recurrence period was 36 months, with 95% confidence intervals from 18 to 36 months. Average follow-up: 48.8 months (18 months, 60 months), 4.76% of patients died. Median survival was 57 months, with 95% confidence interval: 18 - 57 months. Use of radial artery graft in coronary artery bypass graft surgery had good results and rate of articulation. The complication and mortality rate was dependent on the age factor over 70 and the left ventricular ejection fraction below 40%. Taking a radial artery is feasible, safe and effective.
