In the present study simple and rapid UV spectroscopic method was developed to quantify Tolterodine Tartarate (ToT) in bulk and marketed tablets. The λmax of ToT in proposed mediums were 266nm and 284nm respectively and follows linearity in the concentration range 5-30μg/ml with a correlation coefficient 0.9996 and 0.9992. The % recovery of ToT from the marketed tablets were 99.66% and 100.12% with low % RSD values for two proposed mediums and was found to be in good agreement with the labelled claim. The % recovery in the standard addition method was in the range of 100.4 to 101%, with low % RSD indicate the proposed mediums had good reproducibility. The % RSD value < 2 indicate that the method is precise, robust and can be rugged. The above method is a rapid tool for routine quantification of ToT in the bulk and in the pharmaceutical dosage form.
Y. Anand Kumar*, C. Prakash, Abhishek, N. Srinivasulu, C. Madhusri, Keerthana Shetty.