The objective of the present study is to carry out the photochemical investigation and wound healing activity study of different extracts of Scoparia dulcis. Scoparia dulcis Linn belongs to the family Scrophulariaceae. The different extracts of this plant were prepared by successive extraction with petroleum ether, chloroform and ethanol. These extracts) were then taken for preliminary phytochemical screening using standard methods. The wound healing activity of the different extracts of Scoparia dulcis was evaluated by using excision wound model in experimental rats. The petroleum ether extract (PEESD) was found to be having potent wound healing activity on comparison to chloroform (CESD) and ethanol (EESD) extract. Result shows PEESD have significant wound healing activity on comparison with standard Nitrofurazone ointment. The wound healing potential may be due to the presence of triterpinoids and flavonoids phytoconstituents in the petroleum ether extract of the studied plant.

Objective: Sebum or grease produced by sebaceous gland are rinsed off from hairs by using shampoo to make them dirt/oil free. The aim was to evaluate two markedly existing herbal shampoo powder containing natural ingredients, which will stay away from the threat posed by chemical ingredients and hence it can be preferred over the other. Methods: Herbal shampoo were evaluated and studied for organoleptic studies, powder characteristics, physicochemical evaluation and cleaning action. Organoleptic evaluation studies were performed by taking the samples randomly for the parameters like colour, odour, and texture. The powder characteristic like tapped density, bulk density and angle of repose were included in the study. The evaluation includes moisture content determination, pH determination, cleaning ability, foam volume and dirt dispersion. Results: All the two marketed formulations (K1 and M1) offered a suitable practical approach and achieved a better usage. General powder characteristics showed results in specified limits. Physicochemical evaluations, pH determination, ability to remove grease, dirt dispersion and foaming capacity were found to yield satisfactory results for the above mentioned marketed formulation. Conclusion: The marketed herbal shampoo powder K1 showed more foaming and the clarity of the solution is turbid but the other M1 exhibit less foam and more cleaning action, the solution is clear. The two formulations (K1 and M1) yielded satisfactory results but the M1 can be preferred over K1 based on the above mentioned observation.

A simple, rapid, precise, accurate and robust stability-indicating RP-HPLC method has been developed and validated to estimate Saxagliptin hydrochloride and Dapagliflozin in bulk and in tablet form. The samples were isocratically eluted using a C18 (250 cm x 4.6cm*5µ) Primesil ODS column with mobile phase Potassium dihydrogren phosphate Buffer (pH 6.0): Acetonitrile (45:55 v/v) at wavelength 247 nm. A good linear response was obtained in the range from 5-30 μg/mL of Saxagliptin hydrochloride and 10-60 μg/mL of Dapagliflozin. The method was quantitatively evaluated in terms of linearity, precision, accuracy (recovery), selectivity and robustness as per ICH guideline. Forced degradation conditions of hydrolysis (neutral, acidic and alkaline), oxidation, photolysis and thermal stress, as suggested in the ICH guideline Q1A (R2) were estimated. The drug showed instability in hydrolysis (neutral, acidic and alkaline), oxidation, photolysis and thermal stress conditions.

Electrochemical and chemical treatments, such as, storage time without use (STWU), prolonged potential cycling (PPC), high positive potential limits (HPPL) and soaking in a ferric ion solution (SFeIS), affect the conduction properties of poly (o-aminophenol) (POAP). The effect of these treatments on the conducting properties of POAP was studied employing cyclic voltammetry (CV), rotating disc electrode voltammetry (RDEV), electrochemical impedance spectroscopy (EIS) and surface resistance (SR). A review of these studies is presented in this work.

An RP-HPLC method was developed and validated for the Lycopene (Powder form or water suspend able form) in Multivitamin and Multimineral Syrup. The chromatographic system was equipped with C18 a stainless steel column 30 cm x 4.0 mm, packed with octadecylsilane chemically bonded to porous silica or ceramic microparticles (5µm) and wavelength set at 475 nm, in conjunction with a mobile phase of Methanol, Water and Tetrahydrofuran in the ratio of 66:4:30 % v/v at a flow rate of 1.5 ml/min. The retention time of Lycopene was found to be 6 min ±1 min. The separation was performed at ambient temperature. Linearity was observed in the concentration range of 80-120% with correlation coefficient 0.9999 and slope 75145.63 Percentage recovery obtained 99.06-101.83 %. The percentage Assay was found to be 100.25 to 102.61 %.The proposed method is precise, accurate, selective and rapid for the determination of lycopene (Powder form) in Multivitamin and Multimineral Syrup. The proposed method is optimized and validated as per the International Conference on Harmonization (ICH) guidelines.