A new series of thiazolidinone derivatives were synthesized by the reaction of schiff base (2-aminopyridine and 4-dimethyl amino benzaldehyde) with mercaptoacetic acid respectively. The chemical structures of the synthesized compounds were confirmed by means of IR. The different synthesized thiazolidinone derivatives derived from benzaldehyde showed good antibacterial activity against both gram positive and gram negative such as Staphylococcus aureus and Eischerchia coli. In this when compare to compound I, compound II showed more inhibition. The average area of inhibition in millimetre (mm) was calculated and compared with that of the standards gentamycin.

The aim of research work is formulation and optimization of drug release of the anastrozole conventional tablet. The conventional tablet formulations of anastrozole were formulated by using suitable different diluents and other excipients. The tablets are prepared by using direct compression method. The prepared tablets are evaluated in terms of their precompression studies, hardness test, thickness test, weight variation test, friability test and invitro study. All the batches showed good to satisfactory of free flowing properties, hardness, thickness, weight variation, friability, and the values are within the pharmacopeia limit. In vitro dissolution studies showed that the formulation FA-3 gave the maximum percentage of drug release (56.18%) with in 60 mints.

The stability studies is one of the very important parameters of pharmaceutical products. Stability assessment and shelf-life prediction is usually a major focus of a pharmaceutical scientist’s attention in the development of all dosage forms. It is important in the development of small molecule drug products as well, particularly given the importance of the physical state of the drug in determining stability characteristics. Stability testing is utilized for formulated product to prediction of shelf life, determine proper storage conditions and suggest labeling instructions.

The heterocyclic amines are the carcinogenic chemicals. Quinazolines is stable in cold dilute acid and alkaline solutions, but it is destroyed when these solutions are boiled. O- Aminobenzaldehyde, ammonia and formic acid are formed when quinazoline is boiled with hydrochloric acid. Male Wistar Albino rats, weighed 200 ± 20 g were utilized for this study. They were housed in polypropylene cages under standard laboratory conditions (12-h light/ 12-h dark cycle, 21 ± 2 ºC, and relative humidity 55 %). The animals were given standard rodent pellets and tap water ad libitum. The resulting liver dysfunction as marked by the increase of SGPT, SGOT and ALP activities. 4a₁ and 4a₄ decreased the alcohol-induced increase of SGPT, SGOT and ALP activities dose dependently. However, 50 mg/kg bodyweight dose of 4a₄ was found to be most effective.Molinspiration virtual screening toolkit miscreen one can easily develop a screening engine for arbitrary target, provided that several active ligands are known. With the trained model it is possible to screen large libraries of hundreds of thousands of molecules in less than hour, to identify molecules with highest chance to become active drugs or pesticides.

A selective, precise, accurate, linear, rugged and robust for the determination of Ezetimibe tablet dosage form. The method was validated according to ICH and FDA guidelines. Analysis of the drug was performed on Agilent XDB C18 (150mm×4.6 mm, 5μ) column, in an isocratic mode employing di- Sodium Hydrogen Orthophosphate buffer and methanol as the mobile phase in the ratio of 32: 68 v/v  UV-Visible detector at 234nm was found to be suitable for detection. Linearity was observed in the range of 20 -100 μg/ml with correlation coefficient of 0.9997.Sensitivity, accuracy, range, precision, robustness, ruggedness, stability, specificity, limit of detection, limit of quantification and system suitability parameters were validated for the developed method. The developed method was successfully applied to estimate the amount of Ezetimibe in pharmaceutical formulations.