Development and implementation of a simple, precise and accurate area under curve spectroscopic method for the estimation of Remogliflozin etabonate in bulk and pharmaceutical dosage form. The drug indicates that the maximum absorption (λ_max) at 275nm in n-hexane solution and AUC in absorption spectrum is measured in the wavelength range from 270 to 280nm at a concentration range of 2-10µg/ml according to Beer’s law. Linearity analysis showed anR² of 0.9998. The % recovery was found to be 98.5-100.7%. The LOD and LOQ were found to be 0.0130 and 0.039µg/ml. The %RSD was found less than 2. The method has been validated for according for linearity, precision, accuracy, robustness, ruggedness, LOD and LOQ according to ICH guidelines.

Development and implementation of a simple, precise, and accurate area under curve spectroscopic method for the estimation of Ezetimibe in bulk and pharmaceutical dosage form. The drug indicates that the maximum absorption (λ max) at 231nm in Acetonitrile solution and AUC in absorption spectrum is measured in the wavelength range from 226 to 236nm at a concentration range of 9-21µg/ml according to Beer’s law. Linearity analysis showed an R2 of 0.9997. The % recovery was found to be 99-99.36%. The LOD and LOQ were found to be 0.028 and 0.086µg/ml. The %RSD was found less than 2. The method has been validated according to linearity, precision, accuracy, robustness, ruggedness, LOD and LOQ according to ICH guidelines.

This research work was aimed towards developing an oral dosage form having Tamsulosin HCL sustained release (SR). Compressed tablets were tested for in-vitro drug release as per the official dissolution profile. There are various polymers used in trial and error method, among these Eudragit_RSPO and HPMCK_100M were taken in the ratio 1:3, had successfully retarded the release of Tamsulosin hydrochloride for 24 hrs in a rate controlled manner. Hence the present work suggests HPMCK_100M as suitable rate retarding polymer for control release formulation of Tamsulosin hydrochloride and the study recommends in vivo evaluation of the best optimized formula. As per the proto type evaluation results it was concluded that wet granulation is the best possible method of granulation for the present work. Pre-formulation studies were conducted to evaluate the drug and excipients compatibility study. The granules were evaluated for tests like bulk density, tap density, compressibility index before compression.