Underlisence drugs are pharmaceutical products manufactured by companies that bought the active ingredient and rights from the original company to produce identical products that have same trade names and properties, dissolution, disintegration, uniformity of content, amount of API's, stability, bioavailability and impurity profiling. Therefore they are more expensive than other generics produced in the same country. This study shows that there is symmetry between impurity profiles of underlisence and original drugs. British Pharmacopoeia method has been applied by using HPLC-UV. This study shows the importance of impurity profiling not only for API's but also for the finished product to assure safety of the drug treatment.

A simple, sensitive and accurate stability indicating UV-spectrophotometric method has been developed for estimation of carprofen from bulk and pharmaceutical formulation. Method applied is area under curve (AUC) in which area under curve was integrated in the wavelength range of 250.5-280 nm. The λmax of carprofen in methanol:Acetonitrile (30:70) was found to be 261.5 nm. The drug follows linearity in the concentration range 1-5 μg/ml with correlation coefficient value 0.999. The proposed method was applied to pharmaceutical formulation and % amount of drug estimated 99.92% was found in good agreement with the label claim. The accuracy of the method was checked by recovery experiment performed at three different levels i.e., 3,4 and 5 µg/ml. The % recovery was found to be in the range 96%-99.25%. The precision of the method was studied as an intra-day, inter-day variations and repeatability. The % R.S.D. value less than 0.3 indicate that the method is precise. Ruggedness of the proposed method was studied with the help of two analysts. The above method was a rapid and cost-effective quality-control tool for routine analysis of carprofen in bulk and in pharmaceutical dosage form.

Pharmacologically quinazolines possess diverse activities like anticonvulsant, analgesic, antiparkinson’s, sedative, hypnotic, muscle relaxant, enzyme inhibiting, antiviral, antibacterial, antifungal, antimicrobial, antitumour, anti-inflammatory, cardiovascular, antihelminthic, (infestations of parasitic worms such as tape worm or hook worm), antimalarial, antitubercular, antihistaminic, antiulcer and hypoglycaemic activities. A series of novel 3-(4-fluorophenyl) -2-substituted quinazolin-4(3H)-ones were synthesized by the reaction of 3-(4-fluorophenyl)-2hydrazinyl quinazolin-4(3H)-one with various dithiocarbamates. The compounds were tested for their antimicrobial activity using Ciprofloxacin as reference standard. The results of the microbial activity indicate that the test compounds inhibit the microbial growth of bacteria. Compound 4-(4-fluorophenyl)-1-(3-(4-fluorophenyl)-4oxo-3,4-dihydroquinazolin-2-yl)thiosemicarbazideemerged as the most potent compound of the series when compared to the reference standard Ciprofloxacin.

Bovine serum albumin nanoparticles (BSANPs) are reported safe and biocompatible nanodevices that carried out effective site specific drug and gene delivery. Nanoparticles are found to be rapidly being developed to overcome several limitations of previously proposed conventional drug delivery systems employed for cancer treatment. Like, conventional chemotherapy is noted to possess some serious side effects including damage of the immune system and other vital organs due to nonspecific targeting and lack of suitable drug solubility with reduced dose and having low survival rate. So, nanotechnology has provided the new advanced opportunity to get direct access of the cancerous or tumours cells selectively with increased drug localization and improved cellular uptake. BSANPs are accounted a remarkable low-cost and non-toxic drug or desired biological component loaded nanodevices due to exhibiting very excellent easy and natural biodegradation or bioproteolysis. In this work, biodegradation of amylase loaded almond oil, mustard oil, jasmine oil and olive oil driven emulsified BSANPs was performed to carry out the controlled and sustained release of bound amylase in to delivery system when exposed to studied standard 35U of alkaline protease. Almond oil and mustard oil driven Pearl millet amylase conjugated emulsified BSANPs have soon excellent controlled and sustained releasing behaviours in the targeted delivery system. Influential results were drawn from this proposed study to get effective sustained and consistent release of loaded materials from BSANPs. So, this biodegradation or bioproteolytic study of amylase bound BSANPs can be attractive industrial and clinical applicability to carry out improved drug loading capacity for loaded bioactive molecules. And, BSNPS can be programmed for recognizing the targeted diseased cells or tissue and giving selective and accurate drug delivery interactions. As well as, proposed alkaline protease mediated biodegradation study may helpful to map the drug delivery path carried out by drug or gene conjugated emulsified BSANPs with the ease of keeping the concept of naturally occurring proteases in targeted host cells. It can prove effective therapeutic and diagnostic strategy considered in molecular medicine, nanomedicine and regenerative medicine.

Diclofenac is a Non-steroidal Anti Inflammatory drug (NSAIDS). It can shows Anti-inflammatory, Antipyretic, and analgesic activity and Diclofenac is important to Inhibition of Cyclooxygenase (COX I, COX II) Enzyme is responsible for Inhibition of Prostaglandins Synthesis. The Authentication and Preformulation studies associated to pure drug diclofenac is conducted for maintaining their standard and stability. The formulation of Diclofenac Sustained release Tablet is important to give prolonged activity in prolonged drug release in Extended Period of Time for the Long Term Therapeutic activity. The Formulation of Sustained Released Tablet by using Suitable Excipients such as HPMC K 100, Ethyl Cellulose, Talc, Magnesium Stearate. This Diclofenac Sustained released tablet is from by Wet Granulation Method. The Prepared sustained released Tablet is Evaluated In terms of bulk density, tapped density, angle of repose, carr’s Index and, hardness test, weight variation test, friability test and in vitro study. The result associated in Optimized batch is good to Satisfactory and having a good free flowing property. The hardness, weight variation, and friability these values are within the pharmacopeia limit. The in vitro Dissolution studies shows Maximum percentage of release of drug (90.52) with in 190 min.