Medicinal plants are of great importance and becoming potential source for phyto-constituents with varied pharmacological activities. Identification of such plants of potential use in medicine is of significance in this era. Butea monosperma (Lam) (Palash) or Erythrina monosperma belonging to family leguminosae-papilioneae is a medium-sized deciduous tree commonly known as ‘flame of the forest’. Erythrina variegata (Lam) or Erythrina indica species is grown for its variegated leaves and the name “coral tree” is used as a collective term for these plants. The qualitative preliminary phytochemical analysis of the hydroethanolic leaf extracts of B.monosperma and E.variegate showed the presence of glycoside, flavonoid, tannins, alkaloid, phenols, protein, amino acids and saponins in both plant samples. Quantitative studies revealed that the 50% hydroethanolic leaf extract of B.monosperma showed higher constituents of phytochemicals when compared with E.varigatea leaf extract. Both the plant extracts showed significant free radical scavenging activity against the tested free radicals such as hydrogen peroxide, DPPH and reducing power (FRAP) assay. The present study revealed that B.monosperma showed highest Antioxidant activity profile than E.variegate.

Imine reductases having great importance in the synthesis of enantiomerically rich enantiomers which are used for the synthesis of chiral intermediates. A novel process for imine reduction of 5-(2, 5-difluorophenyl)-3, 4-dihydro-2H-pyrrole was achieved to synthesis (R)-2-(2, 5-difluorophenyl) pyrrolidine, which is key intermediate for the synthesis of a highly selective TRK inhibitor, is a CNS active small molecule tyrosine kinase inhibitor of the three TRK protein kinases1-5 and (S)-2-(2, 5-difluorophenyl) pyrrolidine using imine reductase enzyme. High enantioselective reaction was accomplished and confirmed by TLC, DIP mass and HPLC. Further to value addition the imine reductase reaction was performed in plug flow reactor and verified its advantages like reduce in time cycle; impurities; reduction of quantity of catalysts/enzymes; less solvent consumption and avoiding damages of catalyst/enzymes.

A quick, precise and accurate method based on HPTLC has been developed for analysis of Luliconazole. The method was developed and validated for the determination of Luliconazole on pre coated silica gel HPTLC plates using Toluene: methanol: GAA Solution (8:2:0.2V/V/V) as a mobile phase with Densitometric detection at 294nm. The method was validated for linearity, precision, accuracy and robustness. Linearity range for LUL was found 100-500ng/band Correlation coefficient was 0.990. The developed method was precise and robust, % RSD was found less than 2%. % recovery was found to be in range of 101.67-103.61%. LOD and LOQ were 15.48ng/b and 46.92ng/b. Stress degradation studies were performed to evaluate the stability indicating properties and specificity of the method. Degradation study was carried out by exposing of working standard solution of LUL with acid (0.1N HCL at 80oC), base (0.1 N NaOH at 80oC), hydrogen peroxide (3% H2O2), Distilled water (H2O) for 2 hours while one volumetric flask was exposed to UV light (294 nm) and one volumetric flask was exposed to (800 C) for 24 hours and thermal LUL sample at (80oC for 1hr) The degradation was found to be resp. (5.17%, 7.20%, 8.18%, 7.82%, 7.58%, 5.72%)

Pyrimidine," is a", brilliant supply of", grouped bioactive", substances. The adaptability in pharmacological exercises and soundness of the pyrimidine core has propelled restorative scientific experts to acquaint numerous bioactive moieties with the current core to integrate new expected therapeutic specialists. Inside this examination, we utilize some new computational devices for anticipating ingestion, circulation, digestion, end and harmfulness. The pharmacokinetic profile of some novel some pyrimidine analogs. The researched simple doesn't have drug-like properties.

Natural polymers are generally polysaccharides which are polymeric in nature and are obtained from woody and non woody plant parts such as bark, seeds, sap, roots, rhizomes, fruits, leaves and plant gums. The natural polymers are having wide applications with fewer side effects, biodegradable, enhance bioavailability, economic, easily available and have been used in various dosage forms. The review focuses in the overview of natural polymers, properties, chemical constituents of polymer and their uses in dosage forms as excipients.